Effect of DanGuiBoHyulTangGami-Bang on Alopecia and Hair Growth Stimulation
January 2004
DanGuiBoHyulTangGami-Bang DBTG Paeonia lactiflora Cuscuta chinensis Angelica tenuissima 5α-reductase type II Rubus coreanus dermal papilla cell IGF-I KGF HGF hair follicles antioxidant activity Scutellaria baicalensis Vitex rotundifolia NO formation MTT DBTG peony dodder Chinese angelica 5-alpha-reductase type II Korean black raspberry dermal papilla insulin-like growth factor 1 keratinocyte growth factor hepatocyte growth factor hair roots antioxidants baikal skullcap chaste tree nitric oxide MTT assay
TLDR DanGuiBoHyulTangGami-Bang helps hair growth but doesn't extend the growth period or affect hair follicle cells significantly.
The study investigated the effects of DanGuiBoHyulTangGami-Bang (DBTG) and its 15 constituent herbs on hair growth and alopecia. Key findings included that extracts of Paeonia lactiflora, Cuscuta chinensis, and Angelica tenuissima inhibited 5α-reductase type II activity by 75.3%, 63.8%, and 75.5%, respectively. Rubus coreanus showed the highest hair growth index (1.8 vs. control 0.4). However, DBTG did not extend the hair growth period or affect dermal papilla cell DNA, IGF-I, KGF, HGF gene expression, or protein synthesis in hair follicles. The herbs lacked antibacterial activity but demonstrated significant antioxidant activity, particularly Paeonia lactiflora, Scutellaria baicalensis, and Rubus coreanus. Additionally, Vitex rotundifolia and Scutellaria baicalensis effectively controlled NO formation. The extracts exhibited low cell virulence with MTT (IC50) values over 500 μg/mL.