Drug delivery to the hair follicle : role of follicular tight junctions as a biological barrier and the potential for targeting clobetasol nanocarriers

    January 2015 in “ SciDok (Saarland University and State Library) ”
    Christiane Mathes
    TLDR Clobetasol nanocarriers can be effectively delivered to hair follicles, with uptake improved by massage and affected by particle type.
    The study confirmed the porcine ear skin model's suitability for human follicular uptake studies of nanoparticle-based drug delivery systems, focusing on clobetasol nanocarriers. It demonstrated the chemical composition and localization of follicular tight junction proteins in hair follicles using confocal Raman microscopy, qPCR, and immunostaining. The research showed that follicular tight junctions acted as a barrier to xenobiotics, which could be modified using EDTA. The study evaluated three different nanocarriers for clobetasol, finding that while they had similar drug-release profiles and reduced skin permeation compared to dissolved drugs, follicular uptake was dependent on the particle type and was enhanced by massage.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 71 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Best places to get clobetasol?

      in Product  1 upvotes 1 year ago
      The user is considering switching to oral dutasteride, topical minoxidil, retinoic acid, and clobetasol for hair loss treatment, after limited regrowth with finasteride and other topicals. They are seeking a source for clobetasol, as they believe it may help with their condition.

      community This and ketoconazole 2% life changing

      in Ketoconazole  69 upvotes 2 years ago
      The post discusses the user's experience with hair loss treatment using finasteride, clobetasol propionate, and ketoconazole shampoo. The conversation warns about the potential side effects of clobetasol, a powerful topical steroid, and emphasizes its short-term usage.

      community Non responsive diffuse thinning

      in Progress Pictures  9 upvotes 1 month ago
      The user has been experiencing diffuse hair thinning despite using finasteride, minoxidil, dermarolling, clobetasol cream, and PRP sessions. They seek advice on additional treatments and are advised to check vitamin D, iron, and thyroid levels.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  50 upvotes 7 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  415 upvotes 7 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

    Similar Research

    5 / 885 results