Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice

    Juan Zhao, Naoaki Harada, Hiroki Kurihara, Naomi Nakagata, Kenji Okajima
    Image of study
    TLDR Eating isoflavone can help mice grow hair by increasing a growth factor.
    In the study from 2011, researchers found that dietary isoflavone increased insulin-like growth factor-I (IGF-I) production, which in turn promoted hair growth in wild-type (WT) mice. Isoflavone significantly raised CGRP mRNA levels in dorsal root ganglion neurons and IGF-I production in the skin of WT mice, leading to enhanced hair follicle morphogenesis, hair regrowth, and pigmentation. These effects were not observed in CGRP-knockout (CGRP-/-) mice, indicating the importance of CGRP in the process. The study concluded that isoflavones could promote hair growth by increasing IGF-I production in hair follicle dermal papilla cells via the increase of CGRP production in sensory neurons. The number of mice used in each experimental group was five.
    View this study on →

    Cited in this study