Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study
April 2013
in “Clinical Endocrinology”
TLDR Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.
In a retrospective cohort study involving 2,301 women with polycystic ovary syndrome (PCOS) over a follow-up period of more than 12,000 person-years, researchers found high incidence rates of type 2 diabetes mellitus (T2DM) and cardiovascular (CV) events. The incidence rates per 1,000 person-years for T2DM, myocardial infarction (MI), angina, heart failure (HF), stroke, and CV death were 3.6, 0.8, 1.0, 0.3, 0.0, and 0.4, respectively. The study also revealed that women with PCOS over the age of 65 had a prevalence of MI and angina over 27%. Risk factors for these conditions included age, history of hypertension, and smoking. The study concluded that women with PCOS have an increased risk of T2DM and CV events, especially as they age, and that treatment and long-term planning should address these risks. However, the study had limitations such as missing data and the absence of waist circumference measurements for most of the observation period.
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Cited in this study
research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society
Women with PCOS should be screened for heart disease risk and manage their health to prevent it.
research The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
research Metabolic features of the reproductive phenotypes of polycystic ovary syndrome
Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.
research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.