Delivery of nanocarriers with dissolvable microneedles for skin treatments: Approaches and challenges

The document reviews the use of dissolvable microneedles (DMNs) combined with nanocarriers for transdermal drug delivery in treating skin conditions like androgenetic alopecia, psoriasis, and acne. DMNs provide a painless, minimally invasive method to bypass the skin barrier, enhancing drug delivery and patient compliance by creating temporary channels for targeted therapeutic delivery with minimal systemic side effects. The review covers various microneedle types and fabrication methods, noting challenges such as the need for sophisticated equipment and limited needle shapes. While 3D printing offers design flexibility, it also faces material limitations and high costs. Despite these challenges, DMNs represent a promising approach for effective and personalized skin disease treatments.