Epithelial Expression of Cytokeratins 15 and 19 in Vitiligo

May 2016 in “ Journal of Cosmetic Dermatology ”

Fatma Y Saleh, Sherif Awad, Ghada A. Nasif, Christein Halim

cytokeratin 15 cytokeratin 19 vitiligo narrow-band ultraviolet therapy follicular epithelium interfollicular epithelium stem cell markers repigmentation process CK 15 CK 19 UV therapy

Studysummary This study found that the expression of CK 15 and CK 19 in vitiligo patients undergoing phototherapy was correlated with improved repigmentation, suggesting their potential as markers for stem cell stimulation.

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The study investigated the expression of cytokeratins CK15 and CK19 as potential stem cell markers in vitiligo patients undergoing narrow-band ultraviolet therapy. Among 28 patients, CK15 was expressed in 61% and CK19 in 39%, primarily in the follicular and interfollicular epithelium. Expression was more evident in patients under 20 years old, with shorter disease duration, stable disease, and normally pigmented hairs. The presence of these cytokeratins was significantly correlated with the improvement of vitiligo lesions, suggesting their potential as valuable tools for monitoring stem cell stimulation and the repigmentation process in vitiligo.

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Research cited in this study

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research Repigmentation of Poliosis After Epithelial Grafting for Vitiligo

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This study observed that white hair follicles in vitiligo patients may repigment following epithelial grafting and phototherapy, suggesting potential cosmetic improvements in vitiligo treatment.

research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma

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Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

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research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

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This study found that C8/144B antibody exclusively binds to the hair follicle bulge and not the epidermal stratum basale, with cytokeratin 19 serving as a key marker of certain basal keratinocytes that decrease with age.

Epithelial Expression of Cytokeratins 15 and 19 in Vitiligo

Research cited in this study

research Repigmentation of Poliosis After Epithelial Grafting for Vitiligo

research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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