TLDR Cytokeratins 15 and 19 may help track vitiligo treatment progress.
The study investigated the expression of cytokeratins CK15 and CK19 as potential stem cell markers in vitiligo patients undergoing narrow-band ultraviolet therapy. Among 28 patients, CK15 was expressed in 61% and CK19 in 39%, primarily in the follicular and interfollicular epithelium. Expression was more evident in patients under 20 years old, with shorter disease duration, stable disease, and normally pigmented hairs. The presence of these cytokeratins was significantly correlated with the improvement of vitiligo lesions, suggesting their potential as valuable tools for monitoring stem cell stimulation and the repigmentation process in vitiligo.
15 citations
,
January 2013 in “Dermatologic Surgery” Epithelial grafting can effectively repigment white hair in vitiligo patients.
351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
120 citations
,
August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
550 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
949 citations
,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
198 citations
,
March 1999 in “Journal of Investigative Dermatology”
4 citations
,
January 2015 in “Hair therapy & transplantation” Hair follicle stem cells could be used to treat the skin condition vitiligo.
November 2019 in “Harper's Textbook of Pediatric Dermatology” Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
21 citations
,
February 2017 in “Dermatologic surgery” Different techniques for vitiligo treatment work similarly well, with some better for specific body areas.
March 2014 in “Journal of The American Academy of Dermatology” The document lists various dermatology topics, treatments, and diagnostic methods.
January 2025 in “Cellular & Molecular Biology Letters” Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.
