Cutis Verticis Gyrata Heralding a Diagnosis of Primary Systemic Amyloidosis in a Patient with Cardioembolic Stroke

A 48-year-old woman presented with a cardioembolic stroke and was found to have cutis verticis gyrata (CVG), a rare scalp condition characterized by convoluted folds. This led to the diagnosis of primary systemic amyloidosis, confirmed by scalp and tongue biopsies showing amyloid deposits. Despite initial stroke treatment, her condition improved with a regimen of bortezomib, cyclophosphamide, and dexamethasone. The case highlights the importance of recognizing CVG as a potential early indicator of systemic amyloidosis, which could have led to earlier diagnosis and stroke prevention.