Neurobehavioral Protective Properties of Curcumin Against Mercury Chloride Treated Mice Offspring

    October 2018 in “ Saudi Journal of Biological Sciences ”
    Gasem Mohammad Abu-Taweel
    TLDR Curcumin can protect against mercury's harmful effects on brain and behavior.
    The study investigated the neurobehavioral and neurochemical effects of mercuric chloride (HgCl₂) on mice offspring and the protective properties of curcumin. Thirty pregnant mice were divided into six groups, with some receiving curcumin, HgCl₂, or a combination of both. The study found that HgCl₂ exposure led to decreased body weight, delayed hair growth, eye opening, memory and learning deficits, and increased anxiety behaviors in pups. Biochemical tests showed reduced levels of dopamine, serotonin, and acetylcholinesterase in the forebrain of HgCl₂-treated pups. Curcumin administration significantly mitigated these effects, indicating its protective role against HgCl₂-induced neurobehavioral and biochemical disorders. The study concluded that curcumin could be beneficial in counteracting the toxic effects of heavy metals like mercury.
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