CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signaling Pathway to Reduce Ferroptosis and Macrophage Polarization

The study demonstrates that CuATSM enhances wound healing and reduces scarring in mice by modulating the Hippo/YAP signaling pathway. CuATSM promotes macrophage polarization towards the M2 phenotype, reduces inflammation, and inhibits ferroptosis, leading to improved granulation tissue formation, collagen deposition, angiogenesis, and cellular proliferation. It also stimulates hair follicle regeneration and stem cell activation, contributing to scarless healing. The findings suggest CuATSM as a promising therapeutic candidate for improving wound repair and minimizing scarring, with significant effects observed in a model involving 4 mice per group.