Roles of Hippo Signaling Pathway in Size Control of Organ Regeneration

The document explored the Hippo signaling pathway's role in organ size control and regeneration across species, emphasizing its regulation of cell proliferation and apoptosis. It highlighted the pathway's conservation in organisms like flatworms, Drosophila, and mice, with specific focus on Xenopus, where Yap was crucial for tail and limb bud regeneration. The pathway interacted with networks like Wnt and Notch, influencing neural progenitor populations and organ size. Differences in Yap expression in species like Macrostomum lignano and planarians suggested varied mechanisms of regeneration. The study proposed that further research could enhance understanding of organ size control and regeneration in mammals.