The G1/S Transition in Mammalian Stem Cells In Vivo Is Autonomously Regulated by Cell Size

April 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Shicong Xie, Shuyuan Zhang, Gustavo de Medeiros, Prisca Liberali, Jan M. Skotheim

G1/S transition epidermal stem cells RB pathway cell cycle regulation cell-autonomous size control

TLDR Cell size independently controls when stem cells divide.

The study investigates how cell size and division are coordinated in multicellular tissues by tracking single epidermal stem cells in adult mice. It reveals that a cell-autonomous size control mechanism, reliant on the RB pathway, determines the timing of S phase entry based on the cell's size, independent of external environmental factors. This finding challenges previous models of cell cycle regulation in complex tissues and highlights the importance of cell-autonomous size control in regulating cell divisions and contributing to stem cell heterogeneity.

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