Cosmeceutical Treatments for Androgenetic Alopecia

    August 2015
    Michael C. Leo, Howard I. Maibach, Raja K Sivamani
    TLDR AGA is caused by genetics and androgens, treatable with finasteride and minoxidil.
    Androgenetic alopecia (AGA) is a genetic condition leading to hair loss, primarily in men, due to the miniaturization of hair follicles and shortened anagen cycles. The condition is driven by androgens like testosterone and DHT, with higher levels of DHT, androgen receptors, and 5α-reductase found in balding scalps. Eunuchs, individuals without androgen receptors, and those lacking 5α-reductase do not experience baldness. AGA follows a polygenic inheritance pattern, with a strong association with the X chromosome, particularly the EDAR2 gene. Standard treatments for AGA included finasteride, a 5α-reductase inhibitor, and minoxidil.
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