Correlation Between Clinical, Histopathological, and Direct Immunofluorescence Findings in Cases of Cicatricial Alopecias

November 2016 in “ International Journal of Research in Dermatology ”

L Sornakumar, C Shanmuga Sekar, Shivakumar Vignesh

cicatricial alopecias Lichen Planopilaris Discoid Lupus Erythematosus folliculitis decalvans acne keloidalis trichotillomania Cutaneous T-cell Lymphoma morphea fibrosis hyalinized collagen direct immunofluorescence scarring alopecias LPP DLE CTCL

TLDR The study found no significant link between the symptoms, tissue analysis, and immunofluorescence results in scarring hair loss conditions.

The 2016 study "Correlation between clinical, histopathological and direct immunoflourescence findings in cases of cicatricial alopecias" involved 20 cases of cicatricial (scarring) alopecias, a group of disorders causing permanent hair loss due to follicle replacement by fibrosis or hyalinized collagen. The study aimed to find correlations between clinical, histopathological, and direct immunofluorescence findings. After histopathological examination, 8 cases (40%) were confirmed as Lichen Planopilaris (LPP), 6 cases (30%) as Discoid Lupus Erythematosus (DLE), 2 cases (10%) as folliculitis decalvans, and 1 case (5%) each of acne keloidalis, trichotillomania, Cutaneous T-cell Lymphoma (CTCL), and morphea. Of the confirmed LPP cases, 50% were positive for direct immunofluorescence, and of the confirmed DLE cases, 67% were positive for immunofluorescence. However, the study found no statistical significance regarding the correlation between clinical, histopathological, and immunofluorescence findings.

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