Reflectance Confocal Microscopy and Dermoscopy Analysis of a Case of Connective Tissue Nevi

    June 2018 in “ Chinese Journal of Dermatology ”
    Xiao Meng, Bingnan Cui, Yijia Xu, Ling Zhang
    TLDR Connective tissue nevi have distinct features, and reflectance confocal microscopy is useful for early diagnosis.
    The study investigated connective tissue nevi (CTN) using dermoscopy and reflectance confocal microscopy (RCM), analyzing pathological features based on lesion duration. For lesions over 1 year, dermoscopy showed distinct grey-white maculae with clear boundaries, surrounded by brown to black pigments, and various vascular and hair structures. RCM revealed weakened tissue refraction due to thickened epidermis. Lesions under 1 year displayed similar maculae but with increased dermal papillae density and brightness, forming a honeycomb structure. The study concluded that CTN has distinct dermoscopic and RCM characteristics, with RCM being particularly useful for diagnosing early lesions.
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