Correlation Between In Vivo Reflectance Confocal Microscopy and Horizontal Histopathology in Skin Cancer: A Review

    March 2021 in “ Frontiers in oncology ”
    Giuseppe Broggi, Anna Elisa Verzì, Rosario Caltabiano, Giuseppe Micali, Francesco Lacarrubba
    TLDR Reflectance confocal microscopy reliably identifies skin cancer features like horizontal skin tissue sections.
    The review discussed the strong correlation between in vivo reflectance confocal microscopy (RCM) and horizontal histopathology (HHS) in diagnosing skin cancer, highlighting RCM as a non-invasive, real-time imaging technique that provided detailed cellular-level images closely matching traditional histopathological findings. This correlation was particularly evident in conditions like squamous cell carcinoma in situ, mycosis fungoides, and eccrine poroma. The review emphasized that RCM could enhance diagnostic accuracy, reduce the need for biopsies, and improve patient outcomes, validating its use in dermatological practice while acknowledging that conventional histopathology remained the gold standard.
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