Effect of Chamaecyparis Obtusa Oil on Hair Growth-Related Enzyme Activity

This study investigated the effects of Chamaecyparis obtusa oil on hair growth in an alopecia model using C57BL/6 mice. Female mice were divided into three groups: a normal group treated with saline, a positive control group treated with 3% Minoxidil, and an experimental group treated with 3% Chamaecyparis obtusa oil. The treatments were applied topically to the dorsal skin for 4 weeks. The study found that Chamaecyparis obtusa oil accelerated hair regrowth more effectively than the other treatments. Enzyme activities, specifically ALP and γ-GT, were significantly increased in the groups treated with Minoxidil and Chamaecyparis obtusa oil compared to the saline group. The results indicated that 3% Chamaecyparis obtusa oil effectively stimulated hair growth, with γ-GT activity correlating well with the degree of hair growth.