The Benefits of Dual Inhibition of 5α Reductase

September 2006 in “ European Urology Supplements ”

Bob Djavan, Vincenzo Mirone

TLDR Dutasteride reduces DHT and improves BPH symptoms more effectively than finasteride.

The document discussed the benefits of dual inhibition of 5α-reductase in managing benign prostatic hyperplasia (BPH), focusing on dutasteride, which inhibited both type I and type II 5α-reductase, leading to greater suppression of dihydrotestosterone (DHT) than finasteride, which only inhibited type II. In a study with 399 patients, dutasteride reduced DHT levels by 94.7% compared to 70.8% with finasteride and showed more rapid and significant improvements in symptoms and prostate volume reduction over 4 years. However, the document noted that direct comparative studies between dutasteride and finasteride were limited, leaving the question of definitive superiority unresolved.

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Research cited in this study

4 / 4 results

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

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Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.

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