Autologous Regenerative Therapy in Baldness Surgery

January 2025

Domenico Piccolo, Alessandro Gennai, Fabrizio Melfa, Bruno Bovani, Piero Tesauro

Autologous Regenerative Therapy hair restoration surgery follicular viability adipose-derived stem cells stromal vascular fraction SEFFI finasteride minoxidil surgical hair transplantation androgenetic alopecia ART ADSCs SVF guided SEFFI Propecia Rogaine AGA

TLDR Autologous Regenerative Therapy may improve hair restoration by using stem cells from fat.

The chapter discusses the integration of Autologous Regenerative Therapy (ART) in hair restoration surgery, focusing on its potential to improve follicular viability and enhance the surrounding macroenvironment of hair follicles. It highlights the use of adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF), which are obtained through minimally invasive fat harvesting techniques like guided SEFFI. This approach aims to address the limitations of traditional treatments like finasteride, minoxidil, and surgical hair transplantation by offering a more sustainable solution for androgenetic alopecia (AGA) through regenerative cellular components.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review

March 2023 in “Cells”

Stem cell treatments show promise for hair loss but need more research.

research Hair Aging and Hair Disorders in Elderly Patients

November 2022 in “International Journal of Trichology”

Older people often experience changes and problems with their hair.

research Functional Hair Follicle Regeneration: An Updated Review

42 citations , February 2021 in “Signal Transduction and Targeted Therapy”

Hair follicle regeneration possible, more research needed.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations , October 2010 in “Archives of Dermatology”

Finasteride helps hair growth but may cause sexual side effects.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control

158 citations , May 2003 in “Journal of Investigative Dermatology”

Hair growth is influenced by dynamic changes in hair follicle cells, which could help treat hair loss.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations , August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Related Community Posts Join

6 / 17 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community How promising is th RCH-01/Replicel treatment? Is there any new info that suggests it will be as successful as it claims? What other promising treatments are close?

in Technology 12 upvotes 6 years ago

The conversation is about the potential of the RCH-01/Replicel hair loss treatment and its lack of updates since 2013, with the user expressing hope for its success and considering using Minoxidil, finasteride, and dermarolling in the meantime. Other treatments mentioned as promising are Breezula and Tsuji.

community HairClone (UK) finally begins offering its Dermal Papilla Cell Hair Multiplication procedure to humans. In Guatemala.

in Technology 147 upvotes 2 weeks ago

HairClone is offering a Dermal Papilla Cell Hair Multiplication procedure in Guatemala, raising questions about its effectiveness and regulatory reasons for the location. Users express skepticism and curiosity about the treatment's success and potential costs.

community Take finasteride NOW. Life is short.

in Finasteride/Dutasteride 698 upvotes 4 years ago

User encourages taking finasteride for hair loss, stating rare permanent side effects. Replies discuss experiences with finasteride, side effects, effectiveness, and alternative treatments.

community Hair Cloning, Trials were supposed to begin 2020-2021

in Technology 48 upvotes 6 years ago

The conversation discusses hair cloning trials expected to start in 2020-2021 and mentions concerns about potential delays due to the Coronavirus. Treatments like Minoxidil, finasteride, and RU58841 are referenced.

community Amplifica Sees Positive Results for Hair Loss Treatment - Results Show 15% increase in 60 days!

in Research/Science 102 upvotes 1 year ago

Amplifica's new injectable treatment for androgenetic alopecia shows a 15% increase in hair thickness and coarseness in 60 days. The treatment is in early human trials and offers a promising alternative to hormone-related hair loss treatments.

Similar Research

5 / 1000+ results

research Regenerative Strategies for Androgenetic Alopecia: Evidence, Mechanisms, and Translational Pathways

January 2026 in “Cosmetics”

New regenerative treatments show promise in improving hair growth for androgenetic alopecia.

Promises and Pitfalls of Regenerative Therapies for Androgenetic Alopecia: Platelet-Rich Plasma, Photobiomodulation, Stem Cells, and Exosomes

research Promises and Pitfalls of Regenerative Therapies for Androgenetic Alopecia: Platelet-Rich Plasma, Photobiomodulation, Stem Cells, and Exosomes

December 2025 in “Medical Sciences”

Regenerative therapies show promise for hair regrowth, but more research and standardization are needed.

Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

research Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

10 citations , September 2020 in “Archives of Dermatological Research”

Both methods improve hair density and thickness; double-spin may be more effective.

research Adipose-Derived Cellular and Cell-Derived Regenerative Therapies in Dermatology and Aesthetic Rejuvenation

60 citations , June 2019 in “Ageing Research Reviews”

Fat from the body can help improve hair growth and scars when used in skin treatments.

research Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field

August 2024 in “Stem Cell Research & Therapy”

New regenerative therapies show promise for treating hair loss.