Autoimmune Skin Diseases In The Era Of COVID-19: Pathophysiological Insights And Clinical Implications
September 2025
in “
Microorganisms
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary In this review, the authors explore the complex interplay between COVID-19 and autoimmune skin diseases, finding that SARS-CoV-2 may trigger or worsen these conditions, with increased risks following infection and vaccination, particularly with mRNA vaccines.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document reviews the complex relationship between COVID-19 and autoimmune skin diseases (ASDs), such as alopecia areata, psoriasis, and hidradenitis suppurativa, highlighting that SARS-CoV-2 can trigger or exacerbate these conditions through mechanisms like immune dysregulation and cytokine signaling. Epidemiological data indicate increased incidence and flares of ASDs post-COVID-19 infection and vaccination, with mRNA vaccines posing a higher risk for hidradenitis suppurativa flares. Despite initial concerns, biologic therapies for psoriasis and HS do not appear to increase COVID-19 severity. The review underscores the importance of continued research to understand these interactions and improve patient management, emphasizing individualized vaccination planning and long-term monitoring for patients with autoimmune skin diseases.
