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Frontline, gold standard treatment for combatting androgenic alopecia
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glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin
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Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
Research
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research Medication-Induced Hair Loss: An Update
COVID-19 vaccines have been linked to an increase in hair loss conditions.
research Rapidly Progressive Alopecia Universalis After Varicella-Zoster Virus Infection: The Role of Immune Dysregulation and Tofacitinib Treatment
Tofacitinib effectively regrows hair in alopecia universalis triggered by a virus.
research Mycobacterial 65,000 MW Heat-Shock Protein Shares a Carboxy-Terminal Epitope with Human Epidermal Cytokeratin 1/2
A mycobacterial protein shares a similar region with a human skin protein, possibly affecting skin diseases.
research Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders
Psoriasis involves immune and genetic factors, and understanding these can improve treatments.
research Long COVID: Clinical Characteristics, Proposed Pathogenesis and Potential Therapeutic Targets
Long COVID is complex, affects many survivors, and needs more research for effective treatments.
Community Join
5 / 673 resultscommunity People call companies stupid for making very high concentration Topical Fin solutions but I think they overlook the fact that the actual absorption rate of finasteride varies greatly
The conversation discusses how the absorption rate of topical finasteride varies and is not equivalent to its oral form, with only a small percentage reaching the scalp. It also mentions that minoxidil in high concentrations is used topically because only a small amount is absorbed.
community Update: 16 months deep - big 3
The user has seen positive results after 16 months of using topical Finasteride/Minoxidil, microneedling weekly, and Tretinoin for hair loss. There are no reported side effects, and the user advises that the effectiveness of microneedling depends on the pressure applied.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
by
nkrata
in Research
330 upvotes
1 year ago FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Solvent for topical fin with low absorption
The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.
community Does seborrheic dermatitis block absorption of topicals?
User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.