Atopic Dermatitis and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis

June 2025 in “ Frontiers in Immunology ”

Hongli Wang, Min Chen, Tengyue Wang, Wenyu Cai, Xuanlin Li, Lin Huang, Mingzhu Wang

atopic dermatitis autoimmune diseases alopecia areata celiac disease ulcerative colitis genetic factors hormonal factors environmental factors

Studysummary This study found an association between atopic dermatitis and autoimmune diseases in both adults and children, with women more likely to experience these complications, but further research is needed due to limited participant numbers.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This systematic review and meta-analysis analyzed data from 26 studies involving 1,629,723 atopic dermatitis (AD) patients and 15,106,889 controls, finding a significant association between AD and various autoimmune diseases such as alopecia areata, celiac disease, and ulcerative colitis. The study highlights that individuals with AD, particularly women, are at a higher risk of developing these conditions. Despite the strong associations found, the study calls for further research due to limitations like the retrospective nature of most studies and the need for larger, prospective studies. It emphasizes the importance of monitoring autoimmune conditions in AD patients for better clinical management and suggests a multidisciplinary approach due to the complex interplay of genetic, hormonal, and environmental factors.

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Research cited in this study

4 / 4 results

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