Exploring the Impact of Acetylsalicylic Acid and Conditioned Medium Obtained From Mesenchymal Cells, Individually and in Combination, on Cognitive Function, Histological Changes, and Oxidant–Antioxidant Balance in Male Rats With Hippocampal Injury

This study, involving 128 male Wistar rats, examines the effects of acetylsalicylic acid (ASA) and conditioned medium (CM) from mesenchymal stem cells on cognitive function and hippocampal injury. The research found that both ASA and CM, individually and in combination, improved cognitive performance, reduced oxidative stress, and promoted neurogenesis in rats with ethidium bromide-induced hippocampal injury. The combination treatment showed a synergistic effect, enhancing cognitive function and neuroprotection more than either treatment alone. These findings suggest that ASA and CM could offer therapeutic benefits for cognitive impairments and hippocampal damage, although further research is needed to determine long-term efficacy and optimal dosing.