Exploring the Impact of Acetylsalicylic Acid and Conditioned Medium Obtained From Mesenchymal Cells, Individually and in Combination, on Cognitive Function, Histological Changes, and Oxidant–Antioxidant Balance in Male Rats With Hippocampal Injury

    September 2024 in “ Brain and Behavior
    Iman Zangiabadi, Mehran Ilaghi, Ali Shamsara, Seyed Hassan Eftekhar‐Vaghefi, Mona Saheli, Mohammad Shabani
    TLDR ASA and CM may protect the brain and work better together.
    The study investigates the effects of acetylsalicylic acid (ASA), conditioned medium (CM) from adipose tissue-derived mesenchymal stem cells (MSCs), and their combination on cognitive function, histological changes, and oxidant-antioxidant balance in male rats with hippocampal injury. The results suggest that both ASA and CM, individually and in combination, show promise as neuroprotective strategies against brain damage. The findings indicate potential synergistic effects of ASA and CM, suggesting the need for further research to explore these effects more comprehensively.
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