Are Janus Kinase (JAK) Inhibitors Beneficial in the Treatment of Androgenic Alopecia?

October 2021 in “ International Journal of Dermatology ”

Fiore Casale, Katerina Yale, Natasha Atanaskova Mesinkovska

Janus kinase inhibitors JAK inhibitors androgenetic alopecia AGA inflammatory skin conditions hair regrowth hair loss JAKi

TLDR JAK inhibitors do not improve hair regrowth in androgenic alopecia but may prevent further hair loss.

The study investigated the effects of Janus kinase inhibitors (JAKi) on androgenetic alopecia (AGA) in 18 men treated for various inflammatory skin conditions. Over an average treatment duration of 66 weeks, no improvement in AGA was observed, although hair loss did not worsen. This suggests that while JAKi may not stimulate hair regrowth in AGA, they could potentially protect against further hair loss. The study's limitations include a small sample size and lack of histologic analysis. Further long-term studies are needed to fully understand the role of JAKi in treating different types of alopecia.

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Research cited in this study

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research Examination of Androgenetic Alopecia with Serum Biomarkers

7 citations , September 2020 in “Journal of Cosmetic Dermatology”

Serum biomarkers like insulin-like growth factor-1 and vitamin D may help diagnose androgenetic alopecia.

research New and Emerging Therapies for Alopecia Areata

46 citations , April 2020 in “Drugs”

Emerging therapies like JAK inhibitors show promise for hair regrowth in alopecia areata.

research JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis

130 citations , February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

JAK inhibitors are effective for treating alopecia areata, with most patients seeing hair growth after treatment.

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research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

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6 / 6 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 8 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community Novel Formulation To Put An End To Hair Loss Once And For All.

in Research/Science 119 upvotes 1 week ago

A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest.

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in Progress Pictures 151 upvotes 2 years ago

User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

community Article of all potential future cures

in Treatment 25 upvotes 6 months ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

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JAK inhibitors do not improve hair regrowth in androgenic alopecia but may prevent further hair loss.

research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

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research Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients

48 citations , November 2017 in “Journal of the American Academy of Dermatology”

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