TLDR JAK inhibitors do not improve hair regrowth in androgenic alopecia but may prevent further hair loss.
The study investigated the effects of Janus kinase inhibitors (JAKi) on androgenetic alopecia (AGA) in 18 men treated for various inflammatory skin conditions. Over an average treatment duration of 66 weeks, no improvement in AGA was observed, although hair loss did not worsen. This suggests that while JAKi may not stimulate hair regrowth in AGA, they could potentially protect against further hair loss. The study's limitations include a small sample size and lack of histologic analysis. Further long-term studies are needed to fully understand the role of JAKi in treating different types of alopecia.
7 citations,
September 2020 in “Journal of Cosmetic Dermatology” Serum biomarkers like insulin-like growth factor-1 and vitamin D may help diagnose androgenetic alopecia.
130 citations,
February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” JAK inhibitors are effective for treating alopecia areata, with most patients seeing hair growth after treatment.
101 citations,
January 2016 in “Journal of Cutaneous and Aesthetic Surgery” Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.
701 citations,
August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
October 2021 in “International Journal of Dermatology” JAK inhibitors do not improve hair regrowth in androgenic alopecia but may prevent further hair loss.
4 citations,
July 2018 in “PubMed” Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.
48 citations,
November 2017 in “Journal of the American Academy of Dermatology” Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.
