Autoimmune Polyglandular Syndrome Type 2 Presentation With Alopecia Universalis, Hashimoto's Disease, and Addison's Disease

    June 2025 in “ International Medical Case Reports Journal ”
    Karla Denisse Sales-Morales, Nazhira Torres-Neme, Vladimir Barrera-Villanueva, Alejandro Martínez-Carreón
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    TLDR Timely diagnosis and treatment of complex autoimmune diseases like APS2 are crucial to prevent complications and improve life quality.
    This case report details a 30-year-old male with autoimmune polyglandular syndrome type 2 (APS2), presenting with alopecia universalis, Hashimoto’s disease, and Addison’s disease. APS2 is rare and involves primary adrenal insufficiency with autoimmune thyroid disease and/or type 1 diabetes. The case highlights the complexity of autoimmune diseases and the necessity of a multidisciplinary approach for effective diagnosis and management. It stresses the importance of timely recognition and treatment to prevent severe complications and improve quality of life, while also recommending ongoing monitoring for future comorbidities. The report notes the rarity of APS2's association with alopecia universalis, with only two other cases documented.
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