Use of an Alternative Method to Evaluate Erythema Severity in a Clinical Trial: Difference in Vehicle Response with Evaluation of Baseline and Postdose Photographs for Effect of Oxymetazoline Cream 1.0% for Persistent Erythema of Rosacea in a Phase IV Study

November 2018 in “ British Journal of Dermatology ”

Lawrence F. Eichenfield, J.Q. Del Rosso, Jerry Tan, Adelaide A. Hebert, Guy Webster, Julie Harper, Hilary Baldwin, Leon Kircik, Linda Stein‐Gold, Alexandre Kaoukhov, Nancy Alvandi

oxymetazoline erythema rosacea Clinician Erythema Assessment vehicle response baseline photographs postdose photographs persistent facial redness redness assessment

Studysummary In this study, adults with persistent facial erythema of rosacea showed significantly greater improvement when treated with once-daily oxymetazoline cream compared to a vehicle, and using baseline photographs in assessments enhanced the accuracy by reducing perceived vehicle effects.

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