Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment

    Nicola Margiotta, Andreas Bernkop-Schnürch, Valentino Laquintana, Annalisa Cutrignelli, Giuseppe Lopalco, Domenico Tricarico, Fatima Maqoud, Angela Curci, Maria Mastrodonato, Flavia la Forgia, Sergio Fontana, Massimo Franco
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    TLDR A new gel containing minoxidil can treat hair loss effectively, potentially reducing side effects and improving treatment.
    In 2018, researchers developed an alginate-based hydrogel containing a minoxidil/hydroxypropyl-β-cyclodextrin (HP-ß-CD) complex for treating androgenetic alopecia (AGA). The HP-ß-CD increased the aqueous solubility of minoxidil by about 22-fold. The hydrogel allowed minoxidil to permeate the skin without damaging the epidermis and remained stable for three months. The study concluded that these hydrogels could serve as alternative formulations to commercial solutions, potentially reducing side effects and optimizing AGA treatment.
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