Adipose Tissue Protects Against Skin Photodamage Through CD151- And AdipoQ- EVs

    December 2024 in “ Cell Communication and Signaling
    Yanwen Wang, Poh‐Ching Tan, Qingfeng Li, Xuewen Xu, Shuang‐Bai Zhou
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    TLDR Fat tissue vesicles protect skin from UV damage better than stem cell vesicles.
    The study explores the protective role of adipose tissue-derived extracellular vesicles (AT-EVs) against skin photodamage, particularly from UVB exposure. Using nude mouse skin models, it was found that AT-EVs are more effective than those from adipose-derived stem cells (ADSC-EVs) in promoting fibroblast proliferation, enhancing collagen synthesis, and reducing reactive oxygen species (ROS) and DNA damage. This is attributed to the higher expression of CD151 and adiponectin in AT-EVs, which facilitate faster cellular uptake and activate protective pathways like AMPK while inhibiting NF-κB. These findings suggest that AT-EVs could be a promising therapeutic approach for skin photoaging and other related conditions.
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