Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes
May 2020
in “Journal of Investigative Dermatology”
TLDR Adenosine helps human hair grow and prevents hair loss by targeting specific cells.
The study found that adenosine promotes human hair growth and inhibits the transition to the catagen phase in vitro by acting on adenosine receptors expressed in human hair follicles, particularly in the outer root sheath keratinocytes. Adenosine enhances hair shaft elongation, increases intrafollicular proliferation, and prolongs the anagen phase. It also prevents the effect of TGFß2, which is a marker of hair cycle-staging. The study suggests that adenosine may have potential as a hair growth-promoting agent and could be a potential therapeutic target for hair loss-associated diseases.
View this study on jidonline.org →
Cited in this study
research Minoxidil in the treatment of androgenetic alopecia
Minoxidil helps treat pattern hair loss in both men and women.
research The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo
KB2115 (eprotirome) can safely extend the hair growth phase without damaging cells or changing hair color.
research A primer for studying cell cycle dynamics of the human hair follicle
The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.
research Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia
Adenosine treatment thickens hair in Caucasian men with hair loss.
research Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia
Adenosine helps grow thicker hair in Japanese men with hair loss.
research Human hair follicle organ culture: theory, application and perspectives
Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
research Neuroendocrinology of the hair follicle: principles and clinical perspectives
Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.
research The human hair follicle, a bistable organ?
Human hair follicles switch between active and resting phases unpredictably.
research Prolactin—a novel neuroendocrine regulator of human keratin expressionin situ
Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.
research The Hair Follicle as a Dynamic Miniorgan
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double-blind, randomized, placebo-controlled trial
Adenosine lotion improves hair growth and thickness in women with hair loss.
research A Hot New Twist to Hair Biology
Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
Related
research Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes
Adenosine helps human hair grow and prevents hair loss by targeting specific cells.