Biopharmaceutical Properties of Adapalene Loaded Biocompatible Microemulsions

The document discussed the use of microemulsions (MEs) as a method to improve the dermal availability of adapalene (ADA), a retinoid used for treating mild to moderate acne. Due to ADA's poor aqueous solubility, its penetration into target areas like hair follicles and the epidermis was limited. MEs were highlighted as a promising solution for topical drug delivery, offering benefits such as ease of manufacture, high solubilization potential for poorly soluble drugs, reduced side effects, long-term stability, and enhanced drug penetration through the skin.