P-12 ACTH-Independent Cushing Syndrome With Inconclusive Adrenal CT Scan Results
January 2025
in “
JCEM Case Reports
”
Studysummary In this case report, a 21-year-old woman diagnosed with ACTH-independent Cushing syndrome showed improvement in symptoms, including a more regular menstrual cycle and lower hirsutism, after starting treatment with ketoconazole, although she developed hypertension.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 21-year-old woman with ACTH-independent Cushing syndrome presented with symptoms including hirsutism, secondary amenorrhea, and characteristic physical features. Initial adrenal CT scans were inconclusive, but later scans showed adrenal thickening. Laboratory tests confirmed the diagnosis, and treatment with ketoconazole improved her symptoms, including resumption of menstrual cycles and controlled blood pressure with spironolactone. The patient is considering surgical options in the future, and genetic studies are not available. The case highlights the challenges in diagnosing and managing ACTH-independent Cushing syndrome with inconclusive imaging results.
