Application of Acellular Grafts for Extensive Skin Defects: A Review

July 2025 in “ Bulgarian Portal for Open Science ”

Надя Златева-Панайотова

acellular grafts granulation epithelialization secondary wound healing epithelial cells hair follicles

TLDR Granulation and epithelialization are crucial for healing large skin wounds.

The review discusses the healing process of extensive skin defects, focusing on granulation and epithelialization as key stages in secondary wound healing. Epithelialization occurs when the wound cavity is adequately filled with granulation tissue, allowing epithelial cells from preserved skin edges and hair follicles to facilitate healing. The document emphasizes the importance of these processes in effectively managing extensive skin defects.

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