Analyzing the Role of ACE2, AR, MX1, and TMPRSS2 Genetic Markers for COVID-19 Severity

    June 2023 in “ Human Genomics ”
    Silvia Martínez-Diz, Carmen María Morales-Álvarez, Yarmila Garcia-Iglesias, Juan Miguel Guerrero-González, Catalina Romero-Cachinero, Jose María González-Cabezuelo, Francisco Fernández-Rosado, Verónica Arenas-Rodríguez, Rocío López-Cintas, María Jesús Álvarez-Cubero, Luis Javier Martínez-González
    TLDR MX1 and AR genes are linked to milder COVID-19, while TMPRSS2 increases severe risk, especially in women.
    This study examines the genetic markers ACE2, AR, MX1, and TMPRSS2 in relation to COVID-19 severity, involving 329 patients. It highlights that ferritin, D-dimer, CRP, and LDH are effective markers for distinguishing between mild and severe cases. The research found that MX1 and AR are expressed at higher levels in mild cases, with AR expression linked to a decreased risk of severe disease in females. Genetic analysis revealed that G carriers in TMPRSS2 (rs2070788) had a higher risk of severe disease, especially in women. The study suggests these genetic markers could help stratify COVID-19 severity, though further research with larger sample sizes is needed to validate these findings.
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