A study of scarless wound healing through programmed inflammation, proliferation and maturation using a redox balancing nanogel

The study demonstrates the effectiveness of a redox balancing chitosan nanogel with citrate capped Mn₃O₄ nanoparticles in promoting scarless wound healing in a preclinical mice model. The nanogel facilitates the wound healing process by regulating reactive oxygen species (ROS) and involving key signaling molecules and growth factors during hemostasis, inflammation, and proliferation stages, leading to complete maturation. In vitro characterization confirms the nanogel's pH-regulated redox buffering capacity, while in vivo studies on Swiss albino mice highlight the involvement of IL-12, IFN-γ, and α-SMA signaling molecules, as well as angiogenesis, in the healing process.