Novel Genes and Variants Associated with Longevity in Bulgarian Centenarians Revealed by Whole Exome Sequencing DNA Pools: A Pilot Study

    January 2020 in “ Journal of Translational Genetics and Genomics ”
    Dimitar Serbezov, Lubomir Balabanski, Sena Karachanak-Yankova, Radoslava Vazharova, Desislava Nesheva, Zora Hammoudeh, Rada Staneva, Marta Mihaylova, Vera Damyanova, Olga Antonova, Dragomira Nikolova, Savina Hadjidekova, Draga Toncheva
    TLDR Certain genes may help Bulgarians live longer.
    The pilot study investigated genetic variants associated with longevity in Bulgarian centenarians by conducting whole exome sequencing on DNA pools from 32 centenarians and 61 young controls. It identified 47 variants with higher allele frequency in centenarians, suggesting a potential link to longevity. The study focused on three genes—RNF43, WNK1, and NADSYN1—due to their roles in longevity-related processes such as the Wnt signaling pathway, insulin/IGF-1 signaling, and redox balancing. These findings underscored the importance of genetic factors in longevity and the need for population-specific allele frequency databases, while also highlighting the complex genetic regulation of longevity.
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