A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride
December 1998
in “Clinical Pharmacology & Therapeutics”
TLDR Both drugs lower DHT levels, with GI198745 being more effective.
This document presents a model for the turnover of dihydrotestosterone (DHT) in the presence of two 5α-reductase inhibitors, GI198745 and finasteride. The study found that both drugs can lower DHT levels, with GI198745 being more effective due to its greater potency and longer half-life. The model accurately predicted the rates of DHT in healthy men who were given the drugs. The study proposes a model for understanding DHT turnover in the presence of these drugs, which can be useful in treating conditions related to DHT, such as hair loss and benign prostatic hyperplasia.
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Cited in this study
research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride
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research Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects
Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.
research Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
research 5α-Metabolism in Finasteride-Treated Subjects and Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.
research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers*
Finasteride safely lowers DHT levels without affecting testosterone.
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research A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits
research FINASTERIDE INHIBITS 5?-REDUCTASE ACTIVITY IN HUMAN DERMAL FIBROBLASTS: PREDICTION OF ITS THERAPEUTIC APPLICATION IN ANDROGEN-RELATED SKIN DISEASES
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research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.
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