A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice
December 2020
in “Pharmaceutics”
TLDR A mix of tocopherol acetate and L-menthol helps grow hair better than using them separately or using minoxidil.
The study from December 18, 2020, found that a topical mixture of tocopherol acetate, L-menthol, and stevioside significantly promoted hair growth in C57BL/6 mice, more effectively than when tocopherol acetate or L-menthol were used alone. The mixture showed a greater effect on hair growth within 4 weeks compared to the control group or those treated with 3% minoxidil. Transcriptome analysis indicated that tocopherol acetate and L-menthol upregulated genes associated with hair growth, while stevioside alone did not promote hair growth in vivo, despite its in vitro effects on keratinocyte proliferation. The mixture achieved a relative hair growth area of 83.7%, which was significantly higher than the control, and gene expression analysis revealed that approximately 400 genes were upregulated by over 10-fold in the mixture-treated group. The study concluded that the mixture has a significant hair growth-promoting effect, comparable to minoxidil, and suggested that the combination of these compounds could be a potent alternative for hair growth promotion.
View this study on mdpi.com →
Cited in this study
research Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia
Increased PPARGC1α relates to hair thinning in common baldness.
research Evaluating hair growth promoting effects of candidate substance: A review of research methods
The document concludes that while lab results for hair growth promotion are promising, human trials are needed and better testing methods should be developed.
research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review
Some alternative treatments for hair loss might work, but more research is needed.
research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells
Icariin helps mouse hair grow by boosting a growth factor in skin cells.
research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction
STAT5 activation is crucial for starting the hair growth phase.
research Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β‐catenin and MAPK pathway
Certain electric currents can promote hair growth by activating specific cell pathways.
research Peppermint Oil Promotes Hair Growth without Toxic Signs
Peppermint oil can effectively promote hair growth without being toxic.
research Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline
More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
research Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
Related
research A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice
A mix of tocopherol acetate and L-menthol helps grow hair better than using them separately or using minoxidil.
research Hairless controls hair fate decision via Wnt/β–catenin signaling
The Hairless gene is crucial for hair cell development, affecting whether skin cells become hair or skin and oil gland cells.
research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene
Hairless protein affects hair follicle structure by regulating the Dlx3 gene.