A compositionally synergistic approach for the development of a multifunctional bilayer scaffold with antibacterial property for infected and chronic wounds

The study developed a multifunctional bilayer scaffold using cryogelation and electrospinning techniques to treat chronic wounds. The scaffold, composed of curcumin dextran nanoparticles and cerium oxide nanoparticles in a gelatin cryogel layer, and a polyvinyl alcohol-poly (vinyl pyrrolidone)-iodine-potassium iodide electrospun fibrous layer, showed high water uptake, degradation, hemocompatibility, and sustained release of active components. In-vitro studies demonstrated enhanced cell viability, migration, and strong antioxidant and antibacterial activity. In-vivo models showed faster wound closure, infection prevention, and efficient healing with mature epithelialization, hair growth, and collagen deposition, suggesting its potential for advanced wound dressing applications.