Alterations in Endogenous Retinoids with Acute UVB Exposure and in the Progression of Cutaneous Squamous Cell Carcinoma
June 2015
in “
OhioLink ETD Center (Ohio Library and Information Network)
”
New to retinoic acid? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that acute UVB exposure in mice increases the synthesis of retinoic acid in the epidermis, which is necessary for normal repair from UVB light.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study investigated the effects of acute UVB exposure on retinoid metabolism in the epidermis and its role in the progression of cutaneous squamous cell carcinoma (cSCC). Using SKH-1 mice, researchers found that UVB exposure increased the expression of retinoid synthesis, degradation, and binding proteins, suggesting enhanced retinoic acid synthesis in the epidermis. These proteins were found to concentrate in more differentiated epidermal layers. The study also demonstrated that retinoic acid synthesis is crucial for normal UVB repair, as shown by changes in proliferation and differentiation markers with disulfiram treatments. Additionally, the expression of proteins STRA6, DHRS9, and ALDH1A1 varied throughout cSCC development, indicating their potential role in retinoic acid synthesis changes. These findings provided insights into why some retinoid treatments were effective against cSCC and could aid in developing better prevention and treatment strategies.
