3 citations
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August 2021 in “Nutrition research” This study suggests that estrogen regulates vitamin A metabolism in skin tissues in a sex-dependent manner, which may have implications for treating acne, hair loss, and skin immunity.
This article discusses the roles of retinoic acid in cellular differentiation and its side effects like hair loss, but reports no new clinical findings.
232 citations
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January 2002 in “Mechanisms of development” This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.
47 citations
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June 2019 in “Nature Communications” This study found that self-noncoding dsRNA activates TLR3 to stimulate intrinsic retinoic acid synthesis, promoting new hair follicle formation in wounded mice and showing similar gene expression changes in humans treated with rejuvenation lasers.
29 citations
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July 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that in mouse hair follicles, enzymes Aldh1a2 and Aldh1a3 have distinct expression patterns that suggest they are involved in different signaling pathways during the hair cycle.