Dorsal Skin Responses to Subchronic Ultraviolet B Irradiation in Wistar-Derived Hypotrichotic WBN/ILA-Ht Rats

    January 2002 in “ PubMed ”
    Valeria Malcotti, Akira Yasoshima, KIKUKO IMAOKA, Hiroyuki Nakayama, K. Doi
    TLDR Prolonged UVB exposure causes significant skin changes and damage in rats.
    The study investigated the effects of subchronic UVB irradiation on the dorsal skin of Wistar-derived hypotrichotic WBN/ILA-Ht rats over a period of up to 3 months. It was observed that UVB exposure led to hyperplasia of epidermal and hair follicle epithelial cells, parakeratosis, and significant epidermal thickening. There was an increase in proliferating cell nuclear antigen (PCNA)-positive epidermal cells after 1 month. The upper dermis showed edema, capillary congestion, mast cell infiltration, and fibroblast proliferation, with the most intense changes occurring at 3 months. Edema extended to the epidermis, causing intercellular edema and dissociation of epidermal cells. Collagen fiber degeneration was noted in the upper dermis. Although not statistically significant, there was a tendency for increased serum IgE concentration after 2 months. The study provided insights into the skin's response to prolonged UVB exposure in this rat model.
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