Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing

January 2024 in “ Frontiers in Pharmacology ”

Lin Zhao, Jia‐Mei Chen, Bai Bai, Gyeongju Song, Jingwen Zhang, Yu Han, Shiwei Huang, Zhang Wang, Guanghua Lu

topical drug delivery skin barrier stratum corneum transdermal absorption

Studysummary This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism

1 citations , January 2023 in “Science Advances”

This study found that bacterially induced metabolic changes in stem cells can enhance skin and hair follicle regeneration in both mice and humans, suggesting potential strategies for improving recovery after injury.

research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

21 citations , November 2022 in “Frontiers in immunology”

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

research TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions

62 citations , July 2022 in “Science Immunology”

This study discovered that TREM2 macrophages influenced by squalene play a role in acne's development by hindering the killing of Cutibacterium acnes, helping explain why benzoyl peroxide is effective in treatment.

research Therapeutic Application of Microsponges-Based Drug Delivery Systems

4 citations , January 2022 in “Current pharmaceutical design”

This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.

research Bacteria Induce Skin Regeneration via IL-1β Signaling

53 citations , April 2021 in “Cell Host & Microbe”

This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.

research Functional Hair Follicle Regeneration: An Updated Review

42 citations , February 2021 in “Signal Transduction and Targeted Therapy”

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

research Subpopulations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic

50 citations , December 2017 in “British Journal of Dermatology”

This study found that ECMs from papillary and dermal papilla fibroblasts support normal basement membrane formation, suggesting potential improvements for therapeutic biomaterials in skin engineering.