17β-Estradiol Inhibits the Production of RANTES in Human Keratinocytes
March 2003
in “
Journal of Investigative Dermatology
”
17β-estradiol RANTES human keratinocytes TNF-α IL-1β psoriatic skin lesions estrogen receptors nuclear factor κB NF-κB estrogen receptor antagonist ICI 182 780 CREB NF-κB p65 CREB-binding protein E2 tumor necrosis factor alpha interleukin-1 beta psoriasis estrogen receptor nuclear factor kappa B cyclic AMP response element-binding protein
Studysummary This study found that 17β-estradiol inhibited RANTES production in human keratinocytes by suppressing nuclear factor κB activity, suggesting a potential mechanism for 17β-estradiol's modulation of psoriasis-related inflammation.
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