Alopecia Areata in an Adolescent With Inflammatory Bowel Disease

November 2016 in “ Clinical Pediatrics ”

Senthilkumar Sankararaman, Margaret Bobonich, Atiye Aktay

alopecia areata inflammatory bowel disease Crohn's disease methotrexate prednisolone azathioprine ophiasis pattern triamcinolone telogen effluvium dermatology IBD steroid injections

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Prednisolone →

Studysummary A girl with Crohn's disease developed hair loss from her medication, which improved with treatment but later returned.

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Research cited in this study

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research Combined Oral Pulse and Topical Corticosteroid Therapy for Severe Alopecia Areata in Children: A Long-Term Follow-Up Study

28 citations , July 2015 in “Dermatologic therapy”

This study found that combining topical and oral pulse corticosteroid therapy for severe alopecia areata in children led to long-lasting hair regrowth, especially in AA plurifocalis, with no serious side effects reported.

research Hair Loss in Patients with Inflammatory Bowel Disease

18 citations , April 2013 in “Inflammatory Bowel Diseases”

This review discusses the various potential causes of hair loss in patients with inflammatory bowel disease, including telogen effluvium from disease flares, but provides no prevalence data; the authors outline a practical assessment and management approach.

research Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata

70 citations , April 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study found that methotrexate had variable efficacy in treating severe alopecia areata in children, with successful hair regrowth observed in five out of thirteen assessable cases.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Alopecia Areata as Another Immune-Mediated Disease Developed in Patients Treated with Tumor Necrosis Factor-Alpha Blocker Agents

61 citations , June 2010 in “Journal of the European Academy of Dermatology and Venereology”

This study highlights cases of alopecia areata that developed during anti-TNF-α therapy, suggesting a potential link or increased frequency, particularly among individuals with a personal or family history of autoimmune diseases.

research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.

research Interventions for Alopecia Areata

164 citations , April 2008 in “Cochrane library”

This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.