Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

September 2010 in “ Veterinary pathology ”

John P. Sundberg, Douglas K Taylor, Gwendolen Lorch, Jim Miller, Kathleen A. Silva, Beth A. Sundberg, Derry C. Roopenian, Leonard C. Sperling, David E. Ong, Lloyd E. King, Helen B. Everts

primary follicular dystrophy scarring dermatitis C57BL/6 mouse substrains central centrifugal cicatricial alopecia CCCA follicular dystrophy inflammation granuloma formation vitamin A metabolism ADH4 enzyme DHRS9 enzyme

Studysummary This study found that certain C57BL/6 mouse substrains have a genetic vulnerability to skin lesions resembling central centrifugal cicatrical alopecia in humans, potentially worsened by high vitamin A levels.

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