Keratin Expression by Corneal and Limbal Stem Cells During Development

August 2020 in “ Experimental eye research/Experimental Eye Research ”

Winston Whei‐Yang Kao

keratin limbal stem cells K5/K14 K8/K18 K8/K19 intermediate filaments K3/K12 corneal basal cells Meesmann's corneal dystrophy LSCs IF corneal dystrophy

Studysummary This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.

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Research cited in this study

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research Types I and II Keratin Intermediate Filaments

211 citations , April 2018 in “Cold Spring Harbor Perspectives in Biology”

Keratins are crucial for cell structure, growth, and disease risk.

research Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

83 citations , May 2013 in “International Journal of Molecular Sciences”

This review explores embryonic epidermal development and discusses key molecular regulators and roles of the sub-epidermal mesenchyme, but reports no new experimental results.

research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations , February 2012 in “PloS one”

This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.

research Keratin Gene Mutations in Disorders of Human Skin and Its Appendages

185 citations , December 2010 in “Archives of Biochemistry and Biophysics”

Keratin gene mutations cause various skin and hair disorders, but new research offers hope for future treatments.

research The Human Keratins: Biology And Pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research An Unexpected Role for Keratin 10 End Domains in Susceptibility to Skin Cancer

43 citations , October 2006 in “Journal of Cell Science”

In this study, researchers found that contrary to expectations, keratin 10 domains did not reduce cell proliferation and instead increased tumor development in genetically modified mice.

research Transdifferentiation of Corneal Epithelium: Evidence for a Linkage Between the Segregation of Epidermal Stem Cells and the Induction of Hair Follicles During Embryogenesis

55 citations , January 2004 in “The International Journal of Developmental Biology”

This study reports that corneal transient amplifying cells can be reprogrammed into epidermal cells capable of forming hair follicles in response to embryonic dermis signals.

research Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation

36 citations , January 2004 in “European journal of cell biology”

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.