Cutaneous Gene Therapy

    January 2007 in “ Annals of Medicine ”
    Thomas G. Jensen
    Studysummary This review discusses advancements and challenges in cutaneous gene therapy using direct and indirect techniques, noting that while clinical translation has begun, further developments are essential for progress.
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    Research cited in this study 9

    1. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    2. Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells Nature · 2005
    3. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    4. Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra) Plastic and Reconstructive Surgery · 2004
    5. Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia JNCI: Journal of the National Cancer Institute · 2001
    6. An Improved and Rapid Method to Construct Skin Equivalents from Human Hair Follicles and Fibroblasts Experimental dermatology · 2001
    7. Efficient Delivery of Transgenes to Human Hair Follicle Progenitor Cells Using Topical Lipoplex Nature biotechnology · 2000
    8. Localized In Vivo Genotypic and Phenotypic Correction of the Albino Mutation in Skin by RNA-DNA Oligonucleotide Nature biotechnology · 2000
    9. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999