Impact of Alpha-Melanocyte-Stimulating Hormone on Mitochondrial Function in Human Dermal Fibroblasts

November 2025 in “ Journal of Investigative Dermatology ”

Damian Józef Flis, Agatha Stegemann, Andżelika Borkowska, Wiesław Ziółkowski, Michael Böhm

alpha-Melanocyte-stimulating hormone MC1R melanocortin receptor 1 mitochondrial function human dermal fibroblasts oxidative phosphorylation OXPHOS cAMP signaling pathways alpha-MSH

Studysummary Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

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