Antibacterial Potency of an Active Compound from Sansevieria Trifasciata Prain: An Integrated In Vitro and In Silico Study
August 2023
in “
Molecules
”
Studysummary This study found that components derived from Sansevieria trifasciata demonstrated notable antibacterial activity against Escherichia coli and Streptococcus aureus, highlighting potential for developing new antibacterial agents.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study explores the antibacterial potential of a compound isolated from Sansevieria trifasciata Prain, specifically targeting Escherichia coli and Streptococcus aureus. The compound, 5-methyl-11-(2-oxopyridin-1(2H)-yl)undecaneperoxoic acid, was analyzed using in vitro and in silico methods, showing significant inhibitory activity with minimum inhibitory concentrations of 1.95 ppm for both bacteria. Molecular docking and dynamics simulations revealed that the compound has a binding affinity comparable to ciprofloxacin for E. coli's enzyme but slightly weaker for S. aureus. The study suggests the compound's potential as a new antibacterial agent, supported by its ability to reduce bacterial growth significantly.
