Effects of Lespedeza Cuneata Aqueous Extract on Testosterone-Induced Prostatic Hyperplasia

January 2019 in “ Pharmaceutical biology ”

Bong Kyun Park, Chang Won Kim, Jeong Eun Kwon, Manorma Negi, Yong Tae Koo, Sang Hun Lee, Dong Hyun Baek, Young Noh, Se Chan Kang

Lespedeza cuneata testosterone-induced prostatic hyperplasia dihydrotestosterone DHT 5α-reductase inflammatory cytokines proliferating cell nuclear antigen PCNA fibroblast growth factor-2 FGF-2 androgen receptor AR prostate-specific antigen PSA finasteride 5-alpha-reductase Propecia

Studysummary This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.

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