Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin

    May 2012 in “ Molecular and Cellular Endocrinology ”
    Tsukasa Inoue, Yasuhiro Miki, Keiko Abe … Hironobu Sasano
    Studysummary In this study, higher expression levels of aromatase and steroidogenic acute regulatory protein were correlated with increased estrogen synthesis and fewer hair follicles in human skin, suggesting a link to elastic fiber formation and hair growth.
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    Research cited in this study 10

    1. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    2. Androgens and Hair Growth Dermatologic Therapy · 2008
    3. Biology of Estrogens in Skin: Implications for Skin Aging Experimental Dermatology · 2005
    4. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    5. Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003
    6. Testosterone Metabolism in Human Skin Cells In Vitro and Its Interaction with Estradiol and Dutasteride Skin pharmacology and physiology · 2003
    7. Skin Aging and Menopause: Implications for Treatment American Journal of Clinical Dermatology · 2003
    8. Intracrinology and the Skin Hormone Research in Paediatrics · 2000
    9. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    10. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994

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    1. Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin Molecular and Cellular Endocrinology · 2012